Research findings by scientists at LSU Health Sciences Center at Shreveport have identified a gene in mammals that is required for growth of some human cancers.
The study, conducted in an animal model, offers new insight at the molecular level into how prostate and ovarian cancers develop. Further studies have potential to guide development of future therapies to treat prostate and ovarian cancers, the researchers said.
The multidisciplinary team of investigators within the Feist-Weiller Cancer Center of LSUHSC-S studied the role of core binding factor (CBF), previously implicated in the control of cancer-related genes. The researchers found that when they removed the protein CBF-Beta, the cells lost the ability to form tumors.
Results of the study were published in the Journal of Cellular Physiology as a highlighted article in the November issue. Authors of the article are J. Nathan Davis, Donna Rogers, Lisa Adams, Thomas Yong, Jette S. Jung, Bing Cheng, Katie Fennell, Erkut Borazanci, Yara W. Moustafa, Amanda Sun, Runhua Shi, Jonathan Glass, J. Michael Mathis, B. Jill Williams and Shari Meyers
The research effort was led by Drs. Davis and Meyers, both Associate Professors in the Department of Biochemistry and Molecular Biology.
The research was funded by U. S. Department of Defense grant number PC080196 awarded to Dr. Meyers.