According to police, the accident happened shortly after midnight at the bottom of the I-20 off-ramp at Jewell Avenue.
Police tell NBC 6 News that the officer involved was attempting to pull over a motorcycle for a traffic stop. The officer ended up striking another vehicle in the process.
The officer and four others were all taken to a local hospital with non-life threatening injuries.
Jewella Avenue was shut down in both directions underneath I-20 as a result of the crash, but police say the roadway has since reopened.
Authorities are still searching for the motorcyclist.